Myotis Pangenome Project

With 136 species across 6 continents, the genus Myotis provides a rich source of genetic diversity for studying the connection between genotype and phenotype. While nearly all Myotis share the same 2n=44 karyotype, we see a large amount of structural diversity at the sequence level. With the advent of long-read sequencing, a Myotis pangenome provides the perfect system to study how genetic diversity at both the nucleotide and structural level shapes phenotypic diversity and adaptations to local environments.

Related Papers

1. de Sotero-Caio, C. G., Cabral-de Mello, D. C., Calixto, M. da S., Valente, G. T., Martins, C., Loreto, V., de Souza, M. J., & Santos, N. (2017). Centromeric enrichment of LINE-1 retrotransposons and its significance for the chromosome evolution of Phyllostomid bats. Chromosome Research: An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology, 25(3–4), 313–325. https://doi.org/10.1007/s10577-017-9565-9
2. Foley, N. M., Harris, A. J., Bredemeyer, K. R., Ruedi, M., Puechmaille, S. J., Teeling, E. C., Criscitiello, M. F., & Murphy, W. J. (2024). Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation. Cell Genomics, 4(2), 100482. https://doi.org/10.1016/j.xgen.2023.100482
3. Sotero-Caio, C. G., Baker, R. J., & Volleth, M. (2017). Chromosomal evolution in Chiroptera. Genes, 8(10). https://doi.org/10.3390/genes8100272
4. Vazquez, J. M., Lauterbur, M. E., Mottaghinia, S., Bucci, M., Fraser, D., Gray-Sandoval, G., Gaucherand, L., Haidar, Z. R., Han, M., Kohler, W., Lama, T. M., Le Corf, A., Maesen, S., McMillan, D., Li, S., Lo, J., Rey, C., Capel, S. L., Singer, M., … Sudmant, P. H. (2024). Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats. BioRxiv.Org: The Preprint Server for Biology, 2024.10.10.617725. https://doi.org/10.1101/2024.10.10.617725
5. Vujošević, M., Rajičić, M., & Blagojević, J. (2018). B Chromosomes in Populations of Mammals Revisited. Genes, 9(10). https://doi.org/10.3390/genes9100487